| Date | Prefix | Opponent | Location | Time | Results |
| Sunday, October 26 | vs. | N.C. State (EXH) | First Horizon Coliseum (Greensboro, N.C.) | 4:30 PM | L 86-88 |
| Tuesday, November 4 | vs. | North Carolina A&T | Colonial Life Arena (Columbia, S.C.) | 7:00 PM | |
| Sunday, November 9 | vs. | Southern Miss | Colonial Life Arena (Columbia, S.C.) | 6:30 PM | |
| Wednesday, November 12 | vs. | Presbyterian | Colonial Life Arena (Columbia, S.C.) | 7:00 PM | |
| Tuesday, November 18 | vs. | Radford | Colonial Life Arena (Columbia, S.C.) | 7:00 PM | |
| Friday, November 21 | vs. | Butler | The Greenbrier (White Sulphur Springs, W. Va.) | 2:00 PM | |
| Sunday, November 23 | vs. | Northwestern | The Greenbrier (White Sulphur Springs, W. Va.) | 5:00 PM | |
| Friday, November 28 | vs. | Charleston Southern | Colonial Life Arena (Columbia, S.C.) | 4:00 PM | |
| Tuesday, December 2 | vs. | Virginia Tech | Colonial Life Arena (Columbia, S.C.) | 7:00 PM | |
| Saturday, December 6 | vs. | Stetson | Colonial Life Arena (Columbia, S.C.) | 2:00 PM | |
| Saturday, December 13 | vs. | The Citadel | Colonial Life Arena (Columbia, S.C.) | 7:00 PM | |
| Tuesday, December 16 | at | Clemson | Littlejohn Coliseum (Clemson, S.C.) | 7:00 PM | |
| Monday, December 22 | vs. | SC State | Colonial Life Arena (Columbia, S.C.) | 4:00 PM | |
| Tuesday, December 30 | vs. | Albany | Colonial Life Arena (Columbia, S.C.) | 6:00 PM | |
| Saturday, January 3 | vs. | Vanderbilt (SEC) | Colonial Life Arena (Columbia, S.C.) | 2:00 PM | |
| Tuesday, January 6 | at | LSU (SEC) | Pete Maravich Center (Baton Rouge, La.) | 7:00 PM | |
| Saturday, January 10 | vs. | Georgia (SEC) | Colonial Life Arena (Columbia, S.C.) | 2:00 PM | |
| Wednesday, January 14 | at | Arkansas (SEC) | Bud Walton Arena (Fayetteville, Ark.) | 9:00 PM | |
| Saturday, January 17 | at | Auburn (SEC) | Neville Arena (Auburn, Ala.) | 6:00 PM | |
| Tuesday, January 20 | vs. | Oklahoma (SEC) | Colonial Life Arena (Columbia, S.C.) | 7:00 PM | |
| Saturday, January 24 | at | Texas A&M (SEC) | Reed Arena (Bryan-College Station, Texas) | 3:30 PM | |
| Wednesday, January 28 | vs. | Florida (SEC) | Colonial Life Arena (Columbia, S.C.) | 9:00 PM | |
| Saturday, January 31 | vs. | LSU (SEC) | Colonial Life Arena (Columbia, S.C.) | 6:00 PM | |
| Tuesday, February 3 | at | Texas (SEC) | Moody Center (Austin, Texas) | 7:00 PM | |
| Saturday, February 7 | vs. | Missouri (SEC) | Colonial Life Arena (Columbia, S.C.) | 1:00 PM | |
| Saturday, February 14 | at | Alabama (SEC) | Coleman Coliseum (Tuscaloosa, Ala.) | 8:30 PM | |
| Tuesday, February 17 | at | Florida (SEC) | O'Connell Center (Gainesville, Fla.) | 7:00 PM | |
| Saturday, February 21 | vs. | Mississippi State (SEC) | Colonial Life Arena (Columbia, S.C.) | 1:00 PM | |
| Tuesday, February 24 | vs. | Kentucky (SEC) | Colonial Life Arena (Columbia, S.C.) | 7:00 PM | |
| Saturday, February 28 | at | Georgia (SEC) | Stegeman Coliseum (Athens, Ga.) | 3:30 PM | |
| Tuesday, March 3 | vs. | Tennessee (SEC) | Colonial Life Arena (Columbia, S.C.) | 6:00 PM | |
| Saturday, March 7 | at | Ole Miss (SEC) | The Sandy and John Black Pavilion at Ole Miss (Oxford, Miss.) | 1:00 PM | |
| Wed Mar 11 - Sun Mar 15 | vs. | SEC Tournament | Bridgestone Arena (Nashville, Tenn.) | TBA |