| Date | Prefix | Opponent | Location | Time | Results |
| Friday, October 24 | vs. | Anderson (Exh) (EXH) | Columbia, SC | 7:00 PM | W 112-31 |
| Thursday, October 30 | vs. | Bad Boy Mowers Series - Atlanta North Carolina (Exh) (EXH) | Atlanta, GA | 6:00 PM | W 91-82 |
| Monday, November 3 | vs. | Grand Canyon | Columbia, SC | 7:00 PM | W 94-54 |
| Friday, November 7 | vs. | Bowling Green | Columbia, SC | 7:00 PM | |
| Tuesday, November 11 | vs. | Clemson | Columbia, SC | 6:00 PM | |
| Saturday, November 15 | vs. | The Real SC Southern Cal | Los Angeles, CA | 9:00 PM | |
| Wednesday, November 19 | vs. | Winthrop | Columbia, SC | 7:00 PM | |
| Sunday, November 23 | vs. | Queens | Columbia, SC | 2:00 PM | |
| Wednesday, November 26 | vs. | Duke | Las Vegas, NV | 4:30 PM | |
| Thursday, November 27 | vs. | Texas or UCLA | Las Vegas, NV | TBA | |
| Thursday, December 4 | at | ACC/SEC Challenge Louisville | Louisville, KY | 7:00 PM | |
| Sunday, December 7 | vs. | NC Central | Columbia, SC | 12:00 PM | |
| Sunday, December 14 | vs. | Penn State | Columbia, SC | 3:30 PM | |
| Thursday, December 18 | at | USF | Tampa, FL | 7:00 PM | |
| Saturday, December 20 | at | Florida Gulf Coast | Fort Myers, FL | 2:00 PM | |
| Sunday, December 28 | vs. | Providence | Columbia, SC | 12:00 PM | |
| Thursday, January 1 | vs. | Alabama (SEC) | Columbia, SC | 2:00 PM | |
| Sunday, January 4 | at | Florida (SEC) | Gainesville, FL | 2:00 PM | |
| Thursday, January 8 | at | Arkansas (SEC) | Fayetteville, AR | 7:30 PM | |
| Sunday, January 11 | vs. | We Back Pat Georgia (SEC) | Columbia, SC | 2:00 PM | |
| Thursday, January 15 | vs. | Texas (SEC) | Columbia, SC | 7:00 PM | |
| Sunday, January 18 | at | Coppin State | Baltimore, MD | 12:00 PM | |
| Thursday, January 22 | at | Oklahoma (SEC) | Norman, OK | 7:00 PM | |
| Sunday, January 25 | vs. | Vanderbilt (SEC) | Columbia, SC | 3:00 PM | |
| Thursday, January 29 | at | Auburn (SEC) | Auburn, AL | 9:00 PM | |
| Monday, February 2 | at | Texas A&M (SEC) | Bryan-College Station, TX | 8:00 PM | |
| Thursday, February 5 | vs. | Mississippi State (SEC) | Columbia, SC | 6:30 PM | |
| Sunday, February 8 | vs. | Tennessee (SEC) | Columbia, SC | 3:00 PM | |
| Saturday, February 14 | at | LSU (SEC) | Baton Rouge, LA | 8:30 PM | |
| Thursday, February 19 | at | Alabama (SEC) | Tuscaloosa, AL | 8:30 PM | |
| Sunday, February 22 | vs. | Ole Miss (SEC) | Columbia, SC | 12:00 PM | |
| Thursday, February 26 | vs. | Missouri (SEC) | Columbia, SC | 8:00 PM | |
| Sunday, March 1 | at | Kentucky (SEC) | Lexington, KY | 2:00 PM | |
| Wed Mar 4 - Sun Mar 8 | vs. | SEC Tournament | Greenville, SC | TBA |